A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is
a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell …

The porcine model has contributed significantly to biomedical research over many decades.
The similar size and anatomy of pig and human organs make this model particularly …

The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …

The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for
developing idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a …

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70 000
people worldwide. The clinical manifestations of the disease are caused by defects in the …

Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are
unknown. Objectives: To establish mechanisms linking anion transport with the functional …

Animal models for cystic fibrosis (CF) have contributed significantly to our understanding of
disease pathogenesis. Here we describe development and characterization of the first cystic …

Particle tracking is a powerful microscopy technique to quantify the motion of individual
particles at high spatial and temporal resolution in complex fluids and biological specimens …

In recent years, multi-photon 3D laser printing has become a widely used tool for the
fabrication of micro-and nanostructures for a large variety of applications. Typically, thorough …