[HTML][HTML] Cystic fibrosis lung environment and Pseudomonas aeruginosa infection

AY Bhagirath, Y Li, D Somayajula, M Dadashi… - BMC pulmonary …, 2016 - Springer
Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

New insights into cystic fibrosis: molecular switches that regulate CFTR

WB Guggino, BA Stanton - Nature reviews Molecular cell biology, 2006 - nature.com
Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel,
is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed …

Function of aquaporins in female and male reproductive systems

HF Huang, RH He, CC Sun, Y Zhang… - Human reproduction …, 2006 - academic.oup.com
The flow of water and some other small molecules across cell membranes is important in
many of the processes underlying reproduction. The fluid movement is strongly associated …

[HTML][HTML] The multifaceted role of aquaporin-9 in health and its potential as a clinical biomarker

IV da Silva, S Garra, G Calamita, G Soveral - Biomolecules, 2022 - mdpi.com
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox
homeostasis, with proven involvement in a variety of pathophysiological conditions such as …

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners

C Li, AP Naren - Integrative Biology, 2010 - academic.oup.com
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated
chloride channel located primarily at the apical or luminal surfaces of epithelial cells in the …

[HTML][HTML] Aquaporins: New players in breast cancer progression and treatment response

V Charlestin, D Fulkerson, CE Arias Matus… - Frontiers in …, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport
water and other small molecules and ions following an osmotic gradient across cell plasma …

Molecular pathology of the CFTR locus in male infertility

M Claustres - Reproductive biomedicine online, 2005 - Elsevier
Congenital bilateral absence of the vas deferens (CBAVD) is a form of infertility with an
autosomal recessive genetic background in otherwise healthy males. CBAVD is caused by …

Identification of arylsulfonamides as Aquaporin 4 inhibitors

VJ Huber, M Tsujita, M Yamazaki, K Sakimura… - Bioorganic & medicinal …, 2007 - Elsevier
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to
inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at …

Ion channels in the endometrium: regulation of endometrial receptivity and embryo implantation

YC Ruan, H Chen, HC Chan - Human reproduction update, 2014 - academic.oup.com
BACKGROUND Although embryo implantation is a prerequisite for human reproduction, it
remains a poorly understood process. The molecular mechanisms regulating endometrial …

De Graaf's thread: the human epididymis

TT Turner - Journal of andrology, 2008 - Wiley Online Library
The epididymis consists of a single, highly coiled and convoluted tubule that Antoine De
Graaf, the famous 17th‐century anatomist, likened to a thread thickening to a string. The …