The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in
central nervous system (CNS) drug delivery, since they block most molecules from entering …

The capacity of the olfactory epithelium (OE) for lifelong neurogenesis and regeneration
depends on the persistence of neurocompetent stem cells, which self‐renew as well as …

Background Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), the virus
that causes coronavirus disease 2019 (COVID‐19), is responsible for the largest pandemic …

Abstract Introduction: The SARS-CoV-2 virus causes COVID-19, and it is responsible for the
largest pandemic since the 1918 H1N1 influenza outbreak. The classic symptoms of the …

Studies of human genetic disorders have traditionally followed a reductionist paradigm.
Traits are defined as Mendelian or complex based on family pedigree and population data …

BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

A prominent clinical symptom of 2019-novel coronavirus (nCoV) infection is
hyposmia/anosmia (decrease or loss of sense of smell), along with general symptoms such …

Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over
continuously and have a multiciliated dendrite. The extensive changes in gene expression …

Adult neurogenesis in the olfactory epithelium is often depicted as a unidirectional pathway
during homeostasis and repair. We challenge the unidirectionality of this model by showing …

Anosmia, a neuropathogenic condition of loss of smell, has been recognized as a key
pathogenic hallmark of the current pandemic SARS-CoV-2 infection responsible for COVID …