We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Systemic inflammation elicited by sepsis can induce an acute cerebral dysfunction known as
sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common …

Importance Synaptic loss is well established as the major structural correlate of cognitive
impairment in Alzheimer disease (AD). The ability to measure synaptic density in vivo could …

In addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation
is considered a key feature of Alzheimer's disease pathology. Inflammation in Alzheimer's …

Chemical synapses are the predominant neuron-to-neuron contact in the central nervous
system. Presynaptic boutons of neurons contain hundreds of vesicles filled with …

Alzheimer's disease (AD) is a neurodegenerative disorder accounting for over 50% of all
dementia patients and representing a leading cause of death worldwide for the global …

Introduction For 30 years synapse loss has been referred to as the major pathological
correlate of cognitive impairment in Alzheimer's disease (AD). However, this statement is …

Highlights•Oxidative stress is an etiopathogenic event upstream to Aβ-plaques and
neurofibrillary tangles leading to Alzheimer's disease.•Unquenched ROS perturb the …