Promising results in several clinical studies have emphasized the potential of gene therapy
to address important medical needs and initiated a surge of investments in drug …

Gene therapy is becoming a promising therapeutic modality for the treatment of genetic and
acquired disorders. Nonviral approaches as alternative gene transfer vehicles to the popular …

Non-viral vector-mediated transfection is a core technique for in vitro screening of
oligonucleotides. Despite the growing interests in the development of oliogonucleotide …

Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins
and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges …

Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene
transfer because it is non-immunogenic, easy to produce and not oncogenic. The main …

Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …

DNA vaccines are ideal candidates for global vaccination purposes because they are
inexpensive and easy to manufacture on a large scale such that even people living in low …

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

Transmembrane transport of exogenous genes is widely investigated because of high
demand for gene therapy. Both gene carriers and cellular conditions can affect gene …

Despite the long history of nanoparticulate calcium phosphate (CaP) as a non-viral
transfection agent, there has been limited success in attempts to optimize its properties for …