Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria
to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must …

Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the
most successful human pathogens, as over half of the world's population is colonized with …

The nickel-dependent urease enzyme is responsible for the hydrolysis of urea to ammonia
and carbon dioxide. A number of bacteria produce urease (ureolytic bacteria) and are …

Background Helicobacter pylori is well adapted to colonize the epithelial surface of the
human gastric mucosa and can cause persistent infections. In order to infect the gastric …

The secretion of hydrochloric acid by the stomach plays an important role in protecting the
body against pathogens ingested with food or water. A gastric fluid pH of 1 to 2 is deleterious …

Helicobacter pylori causes one of the most common, chronic bacterial infections and is a
primary cause of severe gastric disorders. To unravel the bacterial factors necessary for the …

Helicobacter pylori is the only neutralophile that has been able to colonize the human
stomach by using a variety of acid-adaptive mechanisms. One of the adaptive mechanisms …

The location of Helicobacter pylori in the gastric mucosa of mammals is defined by natural
pH gradients within the gastric mucus, which are more alkaline proximal to the mucosal …

The virulence of pathogenic bacteria is dependent on their adaptation to and survival in the
stressful conditions encountered in their hosts. Helicobacter pylori exclusively colonizes the …

Helicobacter pylori is a gastric-dwelling pathogen responsible, with acid secretion, for peptic
ulcer and a 20-fold increase in the risk of gastric cancer. Several transcriptomes have been …