Small molecular tyrosine kinase inhibitors (smTKIs) are in the centre of the very quickly
expanding area of personalized chemotherapy and oral applicability thereof. The number of …

Quercetin (Que) is a flavonoid associated with high oxygen radical scavenging activity and
potential neuroprotective activity against Alzheimer's disease. Que's oral bioavailability is …

Active pharmaceutical ingredients (APIs) from the purchase and use of medications are
recognized as ubiquitous contaminants of the environment. Ecological impacts can range …

In recent years, the gut microbiome has gained increasing appreciation as a determinant of
the health status of the human host. Bile salts that are secreted into the intestine may be …

Purpose To demonstrate that oral drug absorption is terminated in finite time. To develop
models based on biopharmaceutical/physiological and finite absorption time concepts …

Ketoconazole and posaconazole are both Biopharmaceutics Classification System class 2
drugs (highly permeable, poorly soluble), are structurally similar, and are administered at the …

The pharmaceutical industry has faced significant changes in recent years, primarily
influenced by regulatory standards, market competition, and the need to accelerate drug …

Background Flavonoids possess a rich polypharmacological profile and their biological role
is linked to their oxidation state protecting DNA from oxidative stress damage. However, their …

The purpose of the present work is to develop a non-binary biopharmaceutical classification
system the so called ABΓ system. The original mathematical model used for the …

Biorelevant dissolution is an indispensable tool utilized during formulation development and
optimization for the prediction of in vivo bioavailability of pharmaceutical agents. Within that …