DNA methylation mediated by DNA methyltransferase is an important epigenetic process
that regulates gene expression in mammals, which plays a key role in silencing certain …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available
against acute myelogenous leukemia (AML). Together with anthracyclines, ara-C forms the …

An epigenetic component, especially aberrant DNA methylation pattern, has been shown to
be frequently involved in sporadic breast cancer development. A growing body of literature …

Efficacy of common salvage chemotherapy regimens in patients... : Medicine Efficacy of
common salvage chemotherapy regimens in patients with refractory or relapsed acute myeloid …

MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat
type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone …

Abstract DNA methyltransferase 1 (DNMT1) is the primary enzyme responsible for
maintaining DNA methylation patterns during cellular division, crucial for cancer …

Abstract Clofarabine (2‑chloro‑2'‑fluoro‑2'‑deoxyarabinosyladenine, CIF), a second‑
generation 2'‑deoxyadenosine analog, possesses a variety of anti‑cancer activities …

Clofarabine is a second‐generation purine nucleoside analog and has significant anti‐
leukemic activity as a single agent. It is approved by the United States Food and Drug …

Similar to fludarabine and cladribine, clofarabine (2-chloro-2′-fluoro-2′-
deoxyarabinosyladenine) is resistant to deamination by adenosine deaminase due to the …