Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …

The laboratory mouse is the most widely used animal model for biomedical research, due in
part to its well-annotated genome, wealth of genetic resources, and the ability to precisely …

Muscle bulk in adult healthy humans is highly variable even after height, age, and sex are
accounted for. Low muscle mass, due to fewer and/or smaller constituent muscle fibers …

Background Intramuscular fat (IMF) content and composition have a strong impact on the
nutritional and organoleptic properties of porcine meat. The goal of the current work was to …

There has been extensive discussion of the “Replication Crisis” in many fields, including
genome-wide association studies (GWAS). We explored replication in a mouse model using …

Background Plasminogen activator inhibitor-1 (PAI-1, Serpine1) is an important circulating
fibrinolysis inhibitor. PAI-1 exists in 2 pools, packaged within platelet α-granules and freely …

Muscle fiber cross-sectional area (CSA) and proportion of different fiber types are important
determinants of muscle function and overall metabolism. Genetic variation plays a …

The genetics underlying variation in health‐related musculoskeletal phenotypes can be
investigated in a mouse model. Quantitative trait loci (QTL s) affecting musculoskeletal traits …

The predominance of age-related diseases such as Alzheimer's disease (AD) are projected
to double over the next several decades, which is attributed to the rapidly growing aging …

Genome-wide association studies (GWAS) in multigenerational outbred populations offer
improved mapping precision compared to traditional populations such as F2s. Advanced …