Epigenomics in aortic dissection: From mechanism to therapeutics

Y Tao, G Li, Y Yang, Z Wang, S Wang, X Li, T Yu, X Fu - Life Sciences, 2023 - Elsevier
Aortic dissection (AD) has an unfavorable prognosis. It requires early diagnosis, appropriate
treatment strategies, and suspicion to recognize symptoms; thus, it is commonly described …

Non‐coding RNAs in aortic dissection: from biomarkers to therapeutic targets

M Cheng, Y Yang, H Xin, M Li, T Zong… - Journal of cellular …, 2020 - Wiley Online Library
Aortic dissection (AD) is the rupture of the aortic intima, causing the blood in the cavity to
enter the middle of the arterial wall. Without urgent and proper treatment, the mortality rate …

Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells

B Li, Z Wang, J Hong, Y Che, R Chen… - Clinical and …, 2021 - Wiley Online Library
Background Aortic dissection (AD) and aortic aneurysm (AA) are critical illnesses with an
unclear pathogenetic mechanism that seriously threaten human life. Aortic medial …

[HTML][HTML] Pharmacologic IRE1α kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis

W Zhang, M Wang, K Gao, X Zhong, Y Xie… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Aortic dissection (AD) is a rare but catastrophic disorder, and associated with significant
morbidity among survivors. This study aimed to target IRE1α-XBP1s pathway …

Inhibition of miR‐148a‐3p resists hepatocellular carcinoma progress of hepatitis C virus infection through suppressing c‐Jun and MAPK pathway

Y Deng, J Wang, M Huang, G Xu… - Journal of Cellular and …, 2019 - Wiley Online Library
Objectives The present study was committed to investigate the role of miR‐148a‐3p in HCC
infected with hepatitis C virus (HCV) and the regulatory mechanism of miR‐148a‐3p/c …

The TGF-β pathway plays a key role in aortic aneurysms

T Tingting, F Wenjing, Z Qian, W Hengquan, Z Simin… - Clinica chimica acta, 2020 - Elsevier
Aortic dissection and aortic aneurysms are currently among the most high-risk
cardiovascular diseases due to their rapid onset and high mortality. Although aneurysm …

Emerging role of non-coding RNAs in aortic dissection

W Ding, Y Liu, Z Su, Q Li, J Wang, Y Gao - Biomolecules, 2022 - mdpi.com
Aortic dissection (AD) is a fatal cardiovascular acute disease with high incidence and
mortality, and it seriously threatens patients' lives and health. The pathogenesis of AD …

[HTML][HTML] Irbesartan inhibits metastasis by interrupting the adherence of tumor cell to endothelial cell induced by angiotensin II in hepatocellular carcinoma

LH Feng, HC Sun, XD Zhu, SZ Zhang… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background The use of angiotensin II inhibitors is associated with a low risk of recurrence
and metastasis in hepatocellular carcinoma (HCC) patients. Vascular cell adhesion …

Downregulation of microRNA‐143‐5p is required for the promotion of odontoblasts differentiation of human dental pulp stem cells through the activation of the mitogen …

BL Wang, Z Wang, X Nan, QC Zhang… - Journal of cellular …, 2019 - Wiley Online Library
MicroRNAs (miRNAs) play critical roles in various biological processes including cell
differentiation. Some researchers suggested that the p38 mitogen‐activated protein kinases …

COPD rat model is more susceptible to cold stress and PM2. 5 exposure and the underlying mechanism

K Zhang, L Guo, Q Wei, Q Song, J Liu, J Niu… - Environmental …, 2018 - Elsevier
The purpose of this study is to verify the hypothesis that chronic obstructive pulmonary
disease (COPD) model rat is more susceptible to cold stress and fine particulate matter (PM …