Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

[HTML][HTML] The renin angiotensin system as a therapeutic target in traumatic brain injury

S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Nanoparticle-based drug delivery for the treatment of traumatic brain injury

FS Mohammed, SB Omay, KN Sheth… - Expert opinion on drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Traumatic brain injuries (TBIs) impact the breadth of society and
remain without any approved pharmacological treatments. Despite successful Phase II …

Low energy availability, menstrual dysfunction, and low bone mineral density in individuals with a disability: implications for the para athlete population

CA Blauwet, EM Brook, AS Tenforde, E Broad, CH Hu… - Sports Medicine, 2017 - Springer
Low energy availability, functional hypothalamic amenorrhea, and low bone mineral density
are three interrelated conditions described in athletic women. Although described as the …

Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs

NM Mercado, G Zhang, Z Ying… - Biochimica et Biophysica …, 2022 - Elsevier
Most efforts to understand the pathology of traumatic brain injury (TBI) have been centered
on the brain, ignoring the role played by systemic physiology. Gut-derived serotonin is …

Multiplexed quantitative proteomics reveals proteomic alterations in two rodent traumatic brain injury models

J Park, SH Lee, D Shin, Y Kim, YS Kim… - Journal of Proteome …, 2023 - ACS Publications
In many cases of traumatic brain injury (TBI), conspicuous abnormalities, such as scalp
wounds and intracranial hemorrhages, abate over time. However, many unnoticeable …

Omega-3 fatty acids and vitamin D decrease plasma T-tau, GFAP, and UCH-L1 in experimental traumatic brain injury

AG Scrimgeour, ML Condlin, A Loban… - Frontiers in Nutrition, 2021 - frontiersin.org
Traumatic brain injury (TBI) results in neuronal, axonal and glial damage. Interventions
targeting neuroinflammation to enhance recovery from TBI are needed. Exercise is known to …

Hydrogen sulfide prevents the vascular dysfunction induced by severe traumatic brain injury in rats by reducing reactive oxygen species and modulating eNOS and …

FI López-Preza, SH de la Cruz, C Santiago-Castañeda… - Life Sciences, 2023 - Elsevier
Aim To assess the effects of subchronic administration with NaHS, an exogenous H 2 S
donor, on TBI-induced hypertension and vascular impairments. Main methods Animals …

Longitudinal changes in anthropometrics and impact on self-reported physical function after traumatic brain injury

LAS Chapple, AM Deane, LT Williams… - Critical care and …, 2017 - Elsevier
Background and aims: Patients admitted to the ICU with a traumatic brain injury (TBI) are at
risk of muscle wasting but this has not been quantified. Our aims were to describe …

Genetic diversity drives extreme responses to traumatic brain injury and post-traumatic epilepsy

T Shannon, C Cotter, J Fitzgerald, S Houle… - Experimental …, 2024 - Elsevier
Traumatic brain injury (TBI) is a complex and heterogeneous condition that can cause wide-
spectral neurological sequelae such as behavioral deficits, sleep abnormalities, and post …