Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

The transcription factor ΔNp63 regulates epithelial stem cell function and maintains the
integrity of stratified epithelial tissues by acting as transcriptional repressor or activator …

Epidermal stem cells orchestrate epidermal renewal and timely wound repair through a tight
regulation of self-renewal, proliferation, and differentiation. In culture, human epidermal stem …

Dynamic chemical modifications of RNA represent novel and fundamental mechanisms that
regulate stemness and tissue homeostasis. Rejuvenation and wound repair of mammalian …

Data obtained from cutting-edge research have shown that deregulated epigenetic marks
are critical hallmarks of cancer. Rapidly emerging scientific evidence has helped in …

Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the
human genome that do not encode for proteins. The three main members of this class …

The TP63 is an indispensable transcription factor for development and homeostasis of
epithelia and its derived glandular tissue. It is also involved in female germline cell quality …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

After a skin injury, keratinocytes switch from a state of homeostasis to one of regeneration
leading to the reconstruction of the epidermal barrier. The regulatory mechanism of gene …