Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Angiogenesis inhibitors are a new class of drugs, for which the general rules involving
conventional chemotherapy might not apply. The successful translation of angiogenesis …

Cancer creates a complex tumor microenvironment (TME) composed of immune cells,
stromal cells, blood vessels, and various other cellular and extracellular elements. It is …

This review assembles the laboratory and clinical evidence that cytotoxic chemotherapy and
antiangiogenic therapy are each dependent on endothelial cell apoptosis. During cytotoxic …

Angiogenesis is the process by which new blood vessels are formed from preexisting
vasculature. It is an essential feature of the female reproductive cycle, embryonic …

It is widely accepted that the tumor microenvironment (TUMIC) plays a major role in cancer
and is indispensable for tumor progression. The TUMIC involves many “players” going well …

IFNs are highly pleiotropic cytokines also endowed with marked antiangiogenic activity. In
this study, the mRNA expression profiles of endothelial cells (EC) exposed in vitro to IFN-α …

The intricate interplay between the endothelium and immune cells has been well recognized
in the context of immune responses. However, the fact that this inter-relation extends well …

Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate
preferentially in tumor cells and inhibit tumor growth. These viruses have been considered …