Gastric cancer is one of the leading causes of cancer death worldwide. Because of its
heterogeneity, gastric cancer has been an interesting model for studying carcinogenesis …

Through investigation of hemizygous and homozygous deletions in common human
cancers, including lung cancer, we have cloned and characterized a gene at chromosome …

Methylation associated inactivation of RASSF1, a putative tumor suppressor identified at
3p21. 3, has been frequently observed in several human malignancies, including lung and …

To investigate the role of the Fhit gene in carcinogen induction of neoplasia, we have
inactivated one Fhit allele in mouse embryonic stem cells and produced (129/SvJ× …

Background The aims of this study were to define the clinicopathological features and
prognosis of gastric cancer in young European adults. Methods Between 1990 and 2004 …

Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity,
are among the most common features of human tumours. The short arm of human …

Purpose: WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that
maps to the common fragile site FRA16D on chromosome 16q23. 3–24.1. To investigate the …

Genetic and epigenetic alterations of multiple cancer-related genes and molecules are
implicated in the development and progression of human gastric carcinomas. Reactivation …

Gastric cancer is thought to result from a combination of environmental factors and the
accumulation of specific genetic alterations due to increasing genetic instability, and …

The FHIT gene, located at chromosome 3p14. 2, is a tumor suppressor gene often involved
in tumors resulting from exposure to environmental carcinogens. We studied 46 pairs of …