Bi-and trispecific immune cell engagers for immunotherapy of hematological malignancies

A Tapia-Galisteo, L Álvarez-Vallina, L Sanz - Journal of Hematology & …, 2023 - Springer
Immune cell engagers are engineered antibodies with at least one arm binding a tumor-
associated antigen and at least another one directed against an activating receptor in …

Immunotherapy of multiple myeloma: current status as prologue to the future

HN Abramson - International Journal of Molecular Sciences, 2023 - mdpi.com
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic
shift since the dawn of the current century. This has been driven largely by the introduction of …

Structural insight into CD20/CD3-bispecific antibodies by molecular modeling

ZY Sun, T Liang, Y Zhang, GQ Hou, X Chu… - Computers in Biology …, 2025 - Elsevier
Abstract Non-Hodgkin's Lymphoma (NHL) remains a significant challenge in hematology,
with chemotherapy and radiation therapy as conventional treatment options, albeit with …

Anti-BCMA CAR-T cell-based therapies and bispecific antibodies in the immunotherapy era: are we ready for this?

M Martino, B Gamberi, E Antonioli… - Expert Review of …, 2024 - Taylor & Francis
Introduction Therapeutic strategies against multiple myeloma (MM) have evolved
dramatically in recent decades, with unprecedent results in the treatment landscape …

Progressive Multifocal Leukoencephalopathy Unmasked by Teclistamab in a Refractory Multiple Myeloma Patient

P Arvanitis, D Farmakiotis, A Pelcovits - Current Oncology, 2024 - mdpi.com
This case report describes the development of Progressive Multifocal Leukoencephalopathy
(PML) in a 72-year-old male with relapsed/refractory multiple myeloma (RRMM), following a …

双特异性抗体治疗复发/难治性多发性骨髓瘤的研究进展

刘梦楠, 黄湘华 - 肾脏病与透析肾移植杂志, 2024 - njcndt.com
多发性骨髓瘤是骨髓浆细胞来源的血液系统恶性肿瘤, 目前认为无法治愈且绝大多数患者最终
发展为复发/难治性多发性骨髓瘤. 双特异性抗体治疗是一种新兴的免疫治疗手段 …

Use of venetoclax in t (11; 14) positive relapsed/refractory multiple myeloma: A systematic review

WJ Khan, M Ali, S Hashim, H Nawaz… - Journal of Oncology …, 2024 - journals.sagepub.com
Background The plasma cell malignancy, multiple myeloma (MM), remains incurable
despite advanced treatment protocols. Overexpression of Bcl-2 (an anti-apoptotic protein), in …

Anticuerpos biespecíficos en mieloma múltiple: un nuevo paradigma

V Abello, P Omaña, J Daza - Medicina, 2023 - revistamedicina.net
El mieloma múltiple (MM) es una enfermedad altamente heterogénea e incurable; aún con
los grandes avances que ha tenido el campo en los últimos 20 años, la gran mayoría de los …

Talquetamab: A promising immunotherapy for multiple myeloma

A Tariq, A Wahid, F Asif, M Khan - Rare Tumors, 2023 - journals.sagepub.com
Dear Editor, Multiple myeloma (MM) is a tumor of the plasma cell. This heterogeneous
monoclonal malignancy accounts for about 15% of all yearly reported hematological tumor …

Advances in bispecific antibody therapy for relapsed/refractory multiple myeloma

LIU Mengnan, H Xianghua - Chinese Journal of Nephrology, Dialysis & …, 2024 - njcndt.com
Multiple myeloma is a hematologic malignancy originating from bone marrow plasma cells
and remains incurable. Most patients eventually develop into relapsed/refractory multiple …