Abstract Characterization of transition and intermediate states of reactions provides insights
into their mechanisms and is often achieved through analysis of linear free energy …

This study aimed to establish a new method for determining the stability constants of drug/β-
cyclodextrin (β-CD) complexes when multiple drugs interacting with each other coexist in the …

The study of hemoglobin oxygenation, starting from the classical works of Hill, has laid the
foundation for molecular biophysics. The cooperative nature of oxygen binding to …

Despite the fact that the investigation of the structural and functional properties of
hemoglobin dates back more than 150 years, the topic has not lost its relevance today. The …

A modification is proposed for the Hill equation, which describes the cooperative binding of
a ligand by a macromolecule. A relative coefficient of cooperativity was introduced as a new …

Insulin-degrading enzyme (IDE) is a highly conserved zinc metallopeptidase and is capable
to catalytically cleave several substrates besides insulin, playing a pivotal role in several …

Studies of hemoglobin and its oxygenation and thermodynamic and mathematical models
developed for the purpose allowed substantial advances in biophysics, and equations …

Heterooligomers that undergo ligand‐promoted conformational changes are ubiquitous in
nature and involved in many essential processes. Conformational switching often leads to …

The MF30 monoclonal antibody, which binds to the myosin subfragment-2 (S2), was found
to increase the extent of myofibril shortening. Yet, previous observations found no effect of …

The beautiful structures of single-and multi-domain proteins are clearly ordered in some
fashion but cannot be readily classified using group theory methods that are successfully …