How to build a lichen: from metabolite release to symbiotic interplay

G Pichler, L Muggia, FC Carniel, M Grube… - New …, 2023 - Wiley Online Library
Exposing their vegetative bodies to the light, lichens are outstanding amongst other fungal
symbioses. Not requiring a pre‐established host,'lichenized fungi'build an entirely new …

Linking lichen metabolites to genes: emerging concepts and lessons from molecular biology and metagenomics

G Singh - Journal of Fungi, 2023 - mdpi.com
Lichen secondary metabolites have tremendous pharmaceutical and industrial potential.
Although more than 1000 metabolites have been reported from lichens, less than 10 have …

Depside and depsidone synthesis in lichenized fungi comes into focus through a genome-wide comparison of the olivetoric acid and physodic acid chemotypes of …

G Singh, D Armaleo, F Dal Grande, I Schmitt - Biomolecules, 2021 - mdpi.com
Primary biosynthetic enzymes involved in the synthesis of lichen polyphenolic compounds
depsides and depsidones are non-reducing polyketide synthases (NR-PKSs), and …

Metagenomics Shines Light on the Evolution of “Sunscreen” Pigment Metabolism in the Teloschistales (Lichen-Forming Ascomycota)

T Llewellyn, RW Nowell, A Aptroot… - Genome Biology and …, 2023 - academic.oup.com
Fungi produce a vast number of secondary metabolites that shape their interactions with
other organisms and the environment. Characterizing the genes underpinning metabolite …

Lichen holobionts show compositional structure along elevation

G Rolshausen, F Dal Grande, J Otte… - Molecular …, 2023 - Wiley Online Library
Holobionts are dynamic ecosystems that may respond to abiotic drivers with compositional
changes. Uncovering elevational diversity patterns within these microecosystems can further …

A genomic journey in the secondary metabolite diversity of fungal plant and insect pathogens: From functional to population genomics

E Kuhnert, J Collemare - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Pathogenic fungi produce secondary metabolites (SMs) to control the host and its
environment.•Functional genomics facilitates identification of new SM effectors.•Population …

Circadian clock‐and temperature‐associated genes contribute to overall genomic differentiation along elevation in lichenized fungi

HF Valim, FD Grande, ELY Wong… - Molecular Ecology, 2024 - Wiley Online Library
Circadian regulation is linked to local environmental adaptation, and many species with
broad climatic niches display variation in circadian genes. Here, we hypothesize that …

Chemical properties of key metabolites determine the global distribution of lichens

AH Schweiger, GM Ullmann, NM Nürk… - Ecology …, 2022 - Wiley Online Library
In lichen symbioses, fungal secondary metabolites provide UV protection on which lichen
algae such as trebouxiophycean green algae—the most prominent group of photobionts in …

A candidate gene cluster for the bioactive natural product gyrophoric acid in lichen-forming fungi

G Singh, A Calchera, D Merges, H Valim… - Microbiology …, 2022 - Am Soc Microbiol
Natural products of lichen-forming fungi are structurally diverse and have a variety of
medicinal properties. Despite this, they have limited implementation in industry mostly …

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

N Ahmad, M Ritz, A Calchera, J Otte, I Schmitt… - Journal of Fungi, 2023 - mdpi.com
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and
a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites …