Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Immunologic interplay between HIV/AIDS and COVID-19: adding fuel to the flames?

M Augello, V Bono, R Rovito, C Tincati… - Current HIV/AIDS …, 2023 - Springer
Abstract Purpose of Review HIV/AIDS and COVID-19 have been the major pandemics
overwhelming our times. Given the enduring immune disfunction featuring people living with …

COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis

EA Barreto, AS Cruz, FP Veras… - Proceedings of the …, 2023 - National Acad Sciences
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in
COVID-19 patients. However, it is still unknown whether SARS-CoV-2 directly triggers …

Cardiac tissue model of immune-induced dysfunction reveals the role of free mitochondrial DNA and the therapeutic effects of exosomes

RXZ Lu, N Rafatian, Y Zhao, KT Wagner… - Science …, 2024 - science.org
Despite tremendous progress in the development of mature heart-on-a-chip models, human
cell–based models of myocardial inflammation are lacking. Here, we bioengineered a …

SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry

O Matveeva, Y Nechipurenko, D Lagutkin… - Frontiers in …, 2022 - frontiersin.org
Our review summarizes the evidence that COVID-19 can be complicated by SARS-CoV-2
infection of immune cells. This evidence is widespread and accumulating at an increasing …

SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147

S Shouman, N El-Kholy, AE Hussien… - Cell Communication and …, 2024 - Springer
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and
lymphopenia were found to be associated with severe acute respiratory syndrome …

It's in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19

JV Harte, C Coleman-Vaughan… - Critical Reviews in …, 2023 - Taylor & Francis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to an unprecedented global healthcare crisis. While SARS-CoV-2-associated COVID-19 …

Tonsils are major sites of persistence of SARS-CoV-2 in children

TM Lima, RB Martins, CS Miura, MVO Souza… - Microbiology …, 2023 - Am Soc Microbiol
In the present study, we show that SARS-CoV-2 can infect palatine tonsils, adenoids, and
secretions in children without symptoms of COVID-19, with no history of recent upper airway …

The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression

KI Ivanov, H Yang, R Sun, C Li… - FEMS Microbiology …, 2024 - academic.oup.com
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
widespread changes in epigenetic modifications and chromatin architecture in the host cell …

[PDF][PDF] Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovid, molnupiravir …

V Mitev - Pharmacia, 2023 - pharmacia.pensoft.net
Millions of publications and thousands of clinical trials have not led to the discovery of an
effective treatment for COVID-19. We believe that the reason for this is the inaccurate …