The architecture of the actin cytoskeleton that concentrates at presynapses remains poorly
known, hindering our understanding of its roles in synaptic physiology. In this work, we …

Clathrin-mediated endocytosis (CME) is the major route through which cells internalise
various substances and recycle membrane components. Via the coordinated action of many …

Fes/Cip4 homology Bin/amphiphysin/Rvs (F-BAR) domains, like all BAR domains, are
dimeric units that oligomerize and bind membranes. F-BAR domains are generally coupled …

Current studies on actin function primarily rely on cytoplasmic actin due to the absence of
cellular models specifically expressing nuclear actin. Here, cell models capable of …

Wired neurons form new presynaptic boutons in response to increased synaptic activity,
however the mechanism (s) by which this occurs remains uncertain. Drosophila motor …

Liquid condensate droplets with distinct compositions of proteins and nucleic acids are
widespread in biological cells. While it is known that such droplets, or compartments, can …

Neuronal extracellular vesicles (EVs) are locally released from presynaptic terminals,
carrying cargoes critical for intercellular signaling and disease. EVs are derived from …

Many eukaryotes assemble an actin-and myosin-based cytokinetic ring (CR) on the plasma
membrane (PM) for cell division, but how it is anchored there remains unclear. In …

Following exocytosis at active zones, synaptic vesicle membranes and membrane-bound
proteins must be recycled. The endocytic machinery that drives this recycling accumulates in …

From a presynaptic perspective, neuronal communication mainly relies on two
interdependent events: The fast Ca 2+-triggered fusion of neurotransmitter-containing …