An explorative review on advanced approaches to overcome bacterial resistance by curbing bacterial biofilm formation

F Mohamad, RR Alzahrani, A Alsaadi… - Infection and Drug …, 2023 - Taylor & Francis
The continuous emergence of multidrug-resistant pathogens evoked the development of
innovative approaches targeting virulence factors unique to their pathogenic cascade …

Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii

AK Cain, M Hamidian - PLoS Pathogens, 2023 - journals.plos.org
Antibiotic resistance is a growing global concern in the field of medicine as it renders
bacterial infections difficult to treat and often more severe. Acinetobacter baumannii is a …

High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be …

AMS Shein, DL Wannigama, PG Higgins, C Hurst… - Scientific Reports, 2022 - nature.com
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by
chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily …

Polymyxins: recent advances and challenges

S Yang, H Wang, D Zhao, S Zhang, C Hu - Frontiers in Pharmacology, 2024 - frontiersin.org
Antibiotic resistance is a pressing global health challenge, and polymyxins have emerged
as the last line of defense against multidrug-resistant Gram-negative (MDR-GRN) bacterial …

Current and novel therapies for management of Acinetobacter baumannii-associated pneumonia

AMS Shein, P Hongsing, ORK Smith… - Critical reviews in …, 2024 - Taylor & Francis
Acinetobacter baumannii is a common pathogen associated with hospital-acquired
pneumonia showing increased resistance to carbapenem and colistin antibiotics nowadays …

Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiella pneumoniae infections

DL Wannigama, AMS Shein, C Hurst, PN Monk… - Iscience, 2023 - cell.com
Developing an effective therapy to overcome carbapenemase-positive Klebsiella
pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently …

Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo

J Peng, Y Wang, Z Wu, C Mao, L Li, H Cao… - Drug Design …, 2023 - Taylor & Francis
Introduction Acinetobacter baumannii has become a major difficulty in the treatment of
bacteria-associated infection. The previously reported antimicrobial peptide Cec4 exhibited …

Retained colistin susceptibility in clinical Acinetobacter baumannii isolates with multiple mutations in pmrCAB and lpxACD operons

MM Zafer, AFA Hussein, MH Al-Agamy… - Frontiers in Cellular …, 2023 - frontiersin.org
The progressive increase in the resistance rates to first-and second-line antibiotics has
forced the reuse of colistin as last-line treatment for Acinetobacter baumannii infections, but …

A Review on Colistin Resistance: An Antibiotic of Last Resort

AH Mondal, K Khare, P Saxena, P Debnath… - Microorganisms, 2024 - mdpi.com
Antibiotic resistance has emerged as a significant global public health issue, driven by the
rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously …

First detection of multidrug-resistant and toxigenic Pasteurella aerogenes in sow vaginal discharge: a novel threat to swine health in Thailand

K Keeratikunakorn, K Kaeoket, P Ounjai… - Scientific Reports, 2024 - nature.com
Pasteurella aerogenes has been implicated in reproductive disorders in sows, yet its
prevalence and characteristics in vaginal discharge are not well understood. This study …