Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

Enhancers are cis-regulatory elements that enable precise spatiotemporal patterns of gene
expression during development and are notable for being able to function at large distances …

The control of promoter-proximal pausing and the release of RNA polymerase II (Pol II) is a
widely used mechanism for regulating gene expression in metazoans, especially for genes …

Various factors differentially recognize trimethylated histone H3 lysine 4 (H3K4me3) near
promoters, H3K4me2 just downstream, and promoter-distal H3K4me1 to modulate gene …

In yeast and humans, previous experiences can lead to epigenetic transcriptional memory:
repressed genes that exhibit mitotically heritable changes in chromatin structure and …

Transcription of protein coding genes is accompanied by recruitment of COMPASS to
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …

The SET1/MLL family of histone methyltransferases is conserved in eukaryotes and
regulates transcription by catalyzing histone H3K4 mono-, di-, and tri-methylation. These …

Mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of histone H3
lysine 4 (H3K4) methyltransferases that are required for metazoan development. MLL1 is the …

The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved
family of methyltransferases referred to as complex of proteins associated with Set1 …

In mammalian cells, the SET1/MLL complexes are the main writers of the H3K4 methyl mark
that is associated with active gene expression. The activities of these complexes are …