Mitochondria are key intracellular organelles involved not only in the metabolic state of the
cell, but also in several cellular functions, such as proliferation, Calcium signaling, and lipid …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Cu4O3 is the least explored copper oxide, and its nanoformulation is anticipated to have
important therapeutic potential especially against cancer. The current study aimed to …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …

Mitochondria and peroxisomes are two types of functionally close-related organelles, and
both play essential roles in lipid and ROS metabolism. However, how they physically interact …

Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …

Electrically excitable cells such as neurons transmit long-distance calcium or electrical
signals to regulate their physiological functions. While the molecular underpinnings and …

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycaemia that
seriously affects human health. Diabetic cardiomyopathy (DCM) is a major cardiovascular …

Parkinson's disease (PD) is a neurodegenerative disease caused by multifactorial
pathogenic mechanisms. Familial PD is linked with genetic mutations in genes whose …