One of the leading causes of wound healing delays is bacterial infection, which limits the
process of restoring the histological and functional integrity of the skin. Electrospun …

The emergence of antibiotic-resistant-bacteria is a serious public health threat, which
prompts us to speed up the discovery of novel antibacterial agents. Phage display …

Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …

The sheer size and vast chemical space (ie, diverse repertoire and spatial distribution of
functional groups) underlie peptides' ability to engage in specific interactions with targets of …

The gut microbiome plays a pivotal role in maintaining the health of the hosts; however,
there is accumulating evidence that certain bacteria in the host, termed pathobionts, play …

A paucity of viable programs and pipelines for the discovery of new antibiotics poses a
significant public health threat. The emergence of resistant strains against vancomycin is …

The continuing rise of antibiotic resistance, particularly among Gram-negative pathogens,
threatens to undermine many aspects of modern medical practice. To address this threat …

Non-ribosomal peptides (NRPs) are a rich source of antibiotic candidates. However, it was
recently discovered that resistance to NRPs can be mediated by D-stereoselective …

Cyclic peptides discovered by genetically encoded library technologies have emerged as a
class of promising molecules in chemical biology and drug discovery. Here we review the …

Staphylococcus aureus is a common food-borne pathogenic microorganism that poses a
serious threat to food quality and safety, and can do harm to human health. In the past …