Serotonin is an ancient molecular signal and a recognized neurotransmitter brainwide
distributed with particular presence in hippocampus. Almost all serotonin receptor subtypes …

Fluorescence recovery after photobleaching (FRAP) is a fluorescence microscopy technique
that has attracted a lot of interest in pharmaceutical research during the last decades. The …

The β 2-adrenergic receptor is an important member of the G-protein-coupled receptor
(GPCR) superfamily, whose stability and function are modulated by membrane cholesterol …

The organization and function of the serotonin1A receptor, an important member of the
GPCR family, have been shown to be cholesterol-dependent, although the molecular …

The present study investigated a possible antidepressant-like activity of hesperidin using
two predictive tests for antidepressant effect in mice: the forced swimming test (FST) and the …

Dimerization and oligomerization of G protein-coupled receptors (GPCRs), proposed almost
30 years ago, have crucial relevance for drug design. Indeed, formation of GPCR oligomers …

The serotonin1A receptor is a representative member of the G-protein coupled receptor
(GPCR) superfamily and serves as an important target in the development of therapeutic …

Pore-forming toxins have evolved to induce membrane injury by formation of pores in the
target cell that alter ion homeostasis and lead to cell death. Many pore-forming toxins use …

G protein-coupled receptors (GPCRs) are lipid-regulated transmembrane proteins that play
a central role in cell signaling and pharmacology. Although the role of membrane lipids in …

The dynamics of the gel to fluid phase transformation in 100 nm large unilamellar vesicles
(LUV) of 1, 2-dipalmitoyl (d62)-sn-glycero-3-phosphocholine (d62-DPPC), has been studied …