The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

After cardiovascular disease, cancer is the leading cause of death worldwide with
devastating health and economic consequences, particularly in developing countries. Inter …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Tissue engineering and its clinical application, regenerative medicine, are instructing
multiple approaches to aid in replacing bone loss after defects caused by trauma or cancer …

The ability to print defined patterns of cells and extracellular‐matrix components in three
dimensions has enabled the engineering of simple biological tissues; however, bioprinting …

Bone tissue engineering strategies that recapitulate the developmental process of
endochondral ossification offer a promising route to bone repair. Clinical translation of such …

Clinical translation of cell‐based products is hampered by their limited predictive in vivo
performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue …

Abstract 3D bioprinting offers an excellent opportunity to provide tissue-engineered cartilage
to microtia patients. However, hydrogel-based bioinks are hindered by their dense and cell …

Fractures heal predominantly through the process of endochondral ossification. The classic
model of endochondral ossification holds that chondrocytes mature to hypertrophy, undergo …