Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a …

Cyclic adenosine diphosphoribose (cADPR) is an endogenous Ca2+ mobilizing nucleotide
in many cell types and different species covering protozoa, plants and animals, including …

Transient receptor potential melastatin 2 (TRPM2) is a ligand-gated Ca2+-permeable
nonselective cation channel. Whereas physiological stimuli, such as chemotactic agents …

Adenosine 5′-diphosphoribose (ADPR) activates TRPM2, a Ca2+, Na+, and K+ permeable
cation channel. Activation is induced by ADPR binding to the cytosolic C-terminal NudT9 …

Cyclic ADP-ribose (cADPR) was discovered as a potent Ca2+-mobilising natural compound
in sea urchin eggs. Recently, cADPR was reported to stimulate Ca2+ signallling in several …

The Ca 2+-mobilizing natural compound cyclic ADP-ribose was discovered in sea urchin
egg homogenates. Recently the involvement of cyclic ADP-ribose in Ca 2+ signaling has …

Cyclic ADP-ribose (cADPR) is a signaling molecule that has been shown to regulate calcium
mobilization from intracellular stores in a wide variety of biological systems (reviewed in [1 …

N 1-[(5 ''-O-Phosphorylethoxy) methyl]-5 '-O-phosphorylinosine 5 ', 5 ''-cyclicpyrophosphate
(cIDPRE 2a) and the 8-substituted derivatives 8-bromo-, 8-azido-, 8-amino-, and 8-Cl …

A concise synthesis of five new analogues of the second messenger cADPR (cyclic
adenosine 5 '-diphosphate ribose) is presented. The synthetic plan centered around the key …

Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with
a 1, 2, 3-triazole pyrophosphate bioisostere were synthesised by click-mediated …