Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains

DJ Santana, TR O'Meara - Nature communications, 2021 - nature.com
Candida auris is an emerging healthcare-associated pathogen of global concern. Recent
reports have identified C. auris isolates that grow in cellular aggregates or filaments, often …

Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

C Dunker, M Polke, B Schulze-Richter… - Nature …, 2021 - nature.com
The ability of the fungal pathogen Candida albicans to undergo a yeast-to-hypha transition
is believed to be a key virulence factor, as filaments mediate tissue damage. Here, we show …

Effects of CO2 in fungi

BJ Chadwick, X Lin - Current Opinion in Microbiology, 2024 - Elsevier
Carbon dioxide supplies carbon for photosynthetic species and is a major product of
respiration for all life forms. Inside the human body where CO 2 is a by-product of the …

The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

BJ Chadwick, T Pham, X Xie, LC Ristow, DJ Krysan… - Elife, 2022 - elifesciences.org
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …

Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in …

J Kramara, MJ Kim, TL Ollinger, LC Ristow… - Mbio, 2024 - journals.asm.org
Protein kinases are critical regulatory proteins in both prokaryotes and eukaryotes.
Accordingly, protein kinases represent a common drug target for a wide range of human …

Polyphyllin I Effects Candida albicans via Inhibition of Virulence Factors

AM Sun, YX Wang, GX Hu, L Li… - … and Alternative Medicine, 2023 - Wiley Online Library
Paris polyphylla is often used in Chinese medicine to treat conditions such as carbuncles,
trauma, snake bites, and mosquito bites. In the present study, we investigated the effect and …

Transcription factor FoAce2 regulates virulence, vegetative growth, conidiation, and cell wall homeostasis in Fusarium oxysporum f. sp. cubense

Z Ding, H Lin, L Liu, T Lu, Y Xu, J Peng, Y Ren, J Peng… - Fungal Biology, 2024 - Elsevier
Fusarium wilt of banana, caused by the fungus Fusarium oxysporum f. sp. cubense (Foc), is
a serious fungal disease that affects banana plants globally. To explore the virulence …

The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again

RS Wakade, DJ Krysan - Current genetics, 2021 - Springer
Since its description in S. cerevisiae, the Regulation of Ace2 and Morphogenesis (RAM)
pathway has been studied for nearly 20 years in multiple model and pathogenic fungi. In …

Loss-of-heterozygosity facilitates a fitness valley crossing in experimentally evolved multicellular yeast

B Baselga-Cervera, N Gettle… - Proceedings of the …, 2022 - royalsocietypublishing.org
Determining how adaptive possibilities do or do not become evolutionary realities is central
to understanding the tempo and mode of evolutionary change. Some of the simplest …

Integrated analysis of SR-like protein kinases Sky1 and Sky2 links signaling networks with transcriptional regulation in Candida albicans

CH Luther, P Brandt, S Vylkova, T Dandekar… - Frontiers in Cellular …, 2023 - frontiersin.org
Fungal infections are a major global health burden where Candida albicans is among the
most common fungal pathogen in humans and is a common cause of invasive candidiasis …