Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …

Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …

Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most common
extracranial malignant tumor of childhood and the most common solid tumor of infancy …

This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Members of the large ETS family of transcription factors (TFs) have highly similar DNA‐
binding domains (DBDs)—yet they have diverse functions and activities in physiology and …

Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding
tumor-specific mutant fusion transcription factors that are essential to their molecular …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

Cancer-related human chromosomal translocations are generated through the illegitimate
joining of two non-homologous chromosomes affected by double-strand breaks (DSB) …

Cancer cells must overcome anoikis (detachment-induced death) to successfully
metastasize. Using proteomic screens, we found that distinct oncoproteins upregulate IL1 …