Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets
Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …
whereas axons in the central nervous system are unable to do so. A common and important …
Traumatic optic neuropathy: a review of current studies
B Chen, H Zhang, Q Zhai, H Li, C Wang, Y Wang - Neurosurgical Review, 2022 - Springer
Traumatic optic neuropathy (TON) is a serious complication of craniofacial trauma that
directly or indirectly damages the optic nerve and can cause severe vision loss. The …
directly or indirectly damages the optic nerve and can cause severe vision loss. The …
[HTML][HTML] Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury
Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …
information through differences in cell size, myelination, and the expression of distinct …
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells
Injured neurons in the adult mammalian central nervous system often die and seldom
regenerate axons. To uncover transcriptional pathways that could ameliorate these …
regenerate axons. To uncover transcriptional pathways that could ameliorate these …
Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice
Y Cheng, Y Yin, A Zhang, AM Bernstein… - Nature …, 2022 - nature.com
The inability of neurons to regenerate long axons within the CNS is a major impediment to
improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances …
improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances …
Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea
Purpose This study aimed to uncover novel cell types in heterogenous basal limbus of
human cornea for identifying LSC at single cell resolution. Methods Single cells of human …
human cornea for identifying LSC at single cell resolution. Methods Single cells of human …
Activating transcription factor 3 (ATF3) is a highly conserved pro-regenerative transcription factor in the vertebrate nervous system
The vertebrate nervous system exhibits dramatic variability in regenerative capacity across
species and neuronal populations. For example, while the mammalian central nervous …
species and neuronal populations. For example, while the mammalian central nervous …
Elk-1 regulates retinal ganglion cell axon regeneration after injury
Adult central nervous system (CNS) axons fail to regenerate after injury, and master
regulators of the regenerative program remain to be identified. We analyzed the …
regulators of the regenerative program remain to be identified. We analyzed the …
Vision protection and robust axon regeneration in glaucoma models by membrane-associated Trk receptors
E Nishijima, S Honda, Y Kitamura, K Namekata… - Molecular Therapy, 2023 - cell.com
Activation of neurotrophic factor signaling is a promising therapy for neurodegeneration.
However, the transient nature of ligand-dependent activation limits its effectiveness. In this …
However, the transient nature of ligand-dependent activation limits its effectiveness. In this …