Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Cardiac myocytes are characterized by distinct structural and functional entities involved in
the generation and transmission of the action potential and the excitation-contraction …

Ion channels are transmembrane proteins that conduct specific ions across biological
membranes. Ion channels are present at the onset of many cellular processes, and their …

The large conductance calcium‐and voltage‐activated potassium channel (BKCa) is widely
expressed at the plasma membrane. This channel is involved in a variety of fundamental …

Protein palmitoylation is rapidly emerging as an important determinant in the regulation of
ion channels, including large conductance calcium-activated potassium (BK) channels …

The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high
external and low internal concentration. Many Ca2+-sensing ion channel proteins have …

Ion channels regulate membrane excitation, and mutations of ion channels often cause
serious neurological disorders including epilepsy. Compared with extensive analyses of …

A major gap in our understanding of sensation is how a single sensory neuron can
differentially respond to a multitude of different stimuli (polymodality), such as propio-or …

Abstract The large-conductance Ca 2+-and voltage-activated K+(MaxiK, BK, BK Ca, Slo1, K
Ca 1.1) channel role in cell signalling is becoming apparent as we learn how the channel …

In neurosecretion, allosteric communication between voltage sensors and Ca2+ binding in
BK channels is crucially involved in damping excitatory stimuli. Nevertheless, the voltage …