Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …

Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …

The 'tubulin-code'hypothesis proposes that different tubulin genes or post-translational
modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result …

Complex cortical malformations associated with mutations in tubulin genes: TUBA1A,
TUBA8, TUBB2B, TUBB3, TUBB5 and TUBG1 commonly referred to as tubulinopathies, are …

Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Microtubules form important cytoskeletal structures that play a role in establishing and
maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and …

Sensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise
connectivity, to transform sensation into compensatory behavior. Whether and how motor …

Purpose To estimate diagnostic yield and genotype-phenotype correlations in a cohort of
811 patients with lissencephaly or subcortical band heterotopia. Methods We collected DNA …

Across different cell types and tissues, microtubules are assembled from highly conserved
dimers of α‐and β‐tubulin. Despite their highly similar structures, microtubules have …

A large number of genes encoding for tubulin proteins are expressed in the developing
brain. Each is subject to specific spatial and temporal expression patterns. However, most …