Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Cancer greatly affects the quality of life of humans worldwide and the number of patients
suffering from it is continuously increasing. Over the last century, numerous treatments have …

Epigenetic mechanisms, such as acetylation, methylation, and succinylation, play pivotal
roles in the regulation of multiple normal biological processes, including neuron regulation …

The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …

Histone deacetylase 11 (HDAC11) is a sole member of the class IV HDAC subfamily with
negligible intrinsic deacetylation activity. Here, we report in vitro profiling of HDAC11 …

Background: Studies have shown that the expression of histone deacetylases (HDACs) is
significantly related to the tumor microenvironment (TME) in gastric cancer. However, the …

Histone deacetylase 11 (HDAC11) is the only member of the class IV HDAC, and the latest
member identified. It is highly expressed in brain, heart, kidney and some other organs, and …

Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors
(HDACis) have positioned these agents as promising drug candidates in combatting cancer …

Histone deacetylases deacetylate histone and non-histone protein targets. Aberrant HDAC
expression and function have been observed in several diseases, which make these …