Exercise as potential therapeutic target to modulate Alzheimer's disease pathology in APOE ε4 carriers: a systematic review

S Tokgöz, JAHR Claassen - Cardiology and Therapy, 2021 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease for which no effective
treatment exists at present. Previous research has found that exercise reduces the risk of …

Exploring the role of lipid-binding proteins and oxidative stress in neurodegenerative disorders: A focus on the Neuroprotective effects of Nutraceutical …

G Scarfò, R Piccarducci, S Daniele, F Franzoni… - Antioxidants, 2022 - mdpi.com
The human brain is primarily composed of lipids, and their homeostasis is crucial to carry on
normal neuronal functions. In order to provide an adequate amount of lipid transport in and …

Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism

G Scarfò, S Daniele, E Chelucci, A Rizza, J Fusi… - Scientific Reports, 2023 - nature.com
Aging is the basis for several unfavorable conditions, including cardiovascular diseases
(CVDs). In this sense, regular physical activity (regular PA) has been proven to delay cellular …

Oxidative stress-related signaling pathways predict oocytes' fertilization in vitro and embryo quality

PG Artini, G Scarfò, I Marzi, J Fusi, ME Obino… - International Journal of …, 2022 - mdpi.com
Oocyte development and fertilization are largely influenced by the microenvironment of the
follicular fluid (FF), and the exploration of its molecular/metabolic composition may help in …

[HTML][HTML] Alcohol drinking, apolipoprotein polymorphisms and the risk of cardiovascular diseases

FM Ceci, M Ceccanti, C Petrella, M Vitali… - Current …, 2021 - ncbi.nlm.nih.gov
Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular
disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate …

A systematic review of red blood cells biomarkers in human aging

S Yadav, Deepika, PK Maurya - The Journals of Gerontology …, 2024 - academic.oup.com
Red blood cells (RBCs) have emerged as biomarkers of the aging process as they undergo
several changes in human aging and age-related diseases. The objectives of our study are …

Substances of abuse and the blood brain barrier: Interactions with physical exercise

MA Małkiewicz, A Małecki, M Toborek… - Neuroscience & …, 2020 - Elsevier
Substance use disorders pose a common medical, social and financial problem. Among the
pathomechanisms of substance use disorders, the disruption and increased permeability of …

Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes

V Cela, E Malacarne, MER Obino, I Marzi, F Papini… - Biomedicines, 2021 - mdpi.com
Endometriosis (EMS) pathogenesis has been related to the release of inflammatory
mediators in peritoneal fluid, creating an altered microenvironment that leads to low-grade …

Apolipoprotein E genotype moderation of the association between physical activity and brain health. A systematic review and meta-analysis

AM Pearce, C Marr, M Dewar, AJ Gow - Frontiers in aging …, 2022 - frontiersin.org
Introduction Possession of one or two e4 alleles of the apolipoprotein E (APOE) gene is
associated with cognitive decline and dementia risk. Some evidence suggests that physical …

Apolipoprotein E polymorphism and oxidative stress in human peripheral blood cells: can physical activity reactivate the proteasome system through epigenetic …

R Piccarducci, S Daniele, B Polini… - Oxidative medicine …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is characterized by proteasome activity impairment, oxidative
stress, and epigenetic changes, resulting in β‐amyloid (Aβ) production/degradation …