Physiological parameter values for physiologically based pharmacokinetic models
RP Brown, MD Delp, SL Lindstedt… - Toxicology and …, 1997 - journals.sagepub.com
Physiologically based pharmacokinetic (PBPK) models are being used increasingly by
regulatory agencies to estimate the internal dose of toxic agents or their metabolites to target …
regulatory agencies to estimate the internal dose of toxic agents or their metabolites to target …
“IARC group 2A Carcinogens” reported in cigarette mainstream smoke
CJ Smith, TA Perfetti, MA Rumple, A Rodgman… - Food and chemical …, 2000 - Elsevier
As a follow-up to an earlier study on IARC Group I compounds, further efforts have been
made to evaluate the international literature on cigarette mainstream smoke for reports on …
made to evaluate the international literature on cigarette mainstream smoke for reports on …
Biomarkers: coming of age for environmental health and risk assessment
AP DeCaprio - Environmental Science & Technology, 1997 - ACS Publications
Biological markers, or biomarkers, reflect molecular and cellular alterations that occur along
the temporal and mechanistic pathways connecting exposure to toxic chemicals or physical …
the temporal and mechanistic pathways connecting exposure to toxic chemicals or physical …
Toxicology and epidemiology of 1, 3-butadiene
MW Himmelstein, JF Acquavella, L Recio… - Critical reviews in …, 1997 - Taylor & Francis
Butadiene is a colorless, volatile gas that has high-volume usage in the synthesis of
polybutadiene, styrene-butadiene, and other polymers. Due to its volatile nature, uptake of …
polybutadiene, styrene-butadiene, and other polymers. Due to its volatile nature, uptake of …
In Vitro Metabolism of 8-2 Fluorotelomer Alcohol: Interspecies Comparisons and Metabolic Pathway Refinement
DL Nabb, B Szostek, MW Himmelstein… - Toxicological …, 2007 - academic.oup.com
The detection of perfluorinated organic compounds in the environment has generated
interest in their biological fate. 8-2 Fluorotelomer alcohol (8-2 FTOH, C7F15CF2CH2CH2OH …
interest in their biological fate. 8-2 Fluorotelomer alcohol (8-2 FTOH, C7F15CF2CH2CH2OH …
A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene
JT Cohen, G Carlson, G Charnley… - Journal of Toxicology …, 2002 - Taylor & Francis
A COMPREHENSIVE EVALUATION OF THE POTENTIAL HEALTH RISKS ASSOCIATED WITH
OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO STYRENE Page 1 A …
OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO STYRENE Page 1 A …
Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro …
J Chen, S Zhao, S Wesseling, NI Kramer… - Environmental …, 2023 - ACS Publications
Worldwide use of organophosphate pesticides as agricultural chemicals aims to maintain a
stable food supply, while their toxicity remains a major public health concern. A common …
stable food supply, while their toxicity remains a major public health concern. A common …
Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
The use of laboratory animals for toxicity testing in chemical safety assessment meets
increasing ethical, economic and legislative constraints. The development, validation and …
increasing ethical, economic and legislative constraints. The development, validation and …
Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol …
M Strikwold, B Spenkelink, RA Woutersen… - Archives of …, 2013 - Springer
In vitro assays are often used for the hazard characterisation of compounds, but their
application for quantitative risk assessment purposes is limited. This is because in vitro …
application for quantitative risk assessment purposes is limited. This is because in vitro …
Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and …
Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity.
The aim of this study was to predict the inter-species and inter-ethnic human differences in …
The aim of this study was to predict the inter-species and inter-ethnic human differences in …