Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

Fibrosis is a central pathway that drives progression of multiple chronic diseases, yet few
safe and effective clinical antifibrotic therapies exist. In most fibrotic disorders, transforming …

Fibrotic diseases account for nearly half of all deaths in the developed world. Despite its
importance, the pathogenesis of fibrosis remains poorly understood. Recently, the two …

SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and
2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

The SLITs (SLIT1, SLIT2, and SLIT3) are a family of secreted proteins that mediate positional
interactions between cells and their environment during development by signaling through …

The Slit family of guidance cues binds to Roundabout (Robo) receptors and modulates cell
migration. We report here that ectopic expression of Slit2 and Robo1 or recombinant Slit2 …

Leukocyte migration into tissues is characteristic of inflammation. It is usually measured in
vitro as the average displacement of populations of cells towards a chemokine gradient, not …