Tunable polymeric scaffolds for enzyme immobilization

A Rodriguez-Abetxuko… - … in Bioengineering and …, 2020 - frontiersin.org
The number of methodologies for the immobilization of enzymes using polymeric supports is
continuously growing due to the developments in the fields of biotechnology, polymer …

[HTML][HTML] Self-assembly of protein-polymer conjugates for drug delivery

CA Stevens, K Kaur, HA Klok - Advanced drug delivery reviews, 2021 - Elsevier
Protein-polymer conjugates are a class of molecules that combine the stability of polymers
with the diversity, specificity, and functionality of biomolecules. These bioconjugates can …

100th Anniversary of Macromolecular Science Viewpoint: Poly(N-isopropylacrylamide)-Based Thermally Responsive Micelles

GF Luo, WH Chen, XZ Zhang - ACS Macro Letters, 2020 - ACS Publications
Poly (N-isopropylacrylamide)(PNIPAAm)-based thermally responsive micelles are of great
importance as smart materials for a number of applications such as drug delivery and …

Molecular dynamics simulations for rationalizing polymer bioconjugation strategies: Challenges, recent developments, and future opportunities

J Kehrein, C Sotriffer - ACS Biomaterials Science & Engineering, 2023 - ACS Publications
The covalent modification of proteins with polymers is a well-established method for
improving the pharmacokinetic properties of therapeutically valuable biologics. The …

Protein materials engineering with DNA

JR McMillan, OG Hayes, PH Winegar… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Proteins are a class of nanoscale building block with remarkable chemical
complexity and sophistication: their diverse functions, shapes, and symmetry as well as …

How to Characterize the Protein Structure and Polymer Conformation in Protein‐Polymer Conjugates–a Perspective

M Mathieu‐Gaedke, A Böker… - … Chemistry and Physics, 2023 - Wiley Online Library
Proteins, having miscellaneous properties perfected by nature over millions of years, are
attractive for many biomedical and industrial applications. The exploitation of proteins offers …

Predicting protein–polymer block copolymer self-assembly from protein properties

A Huang, JM Paloni, A Wang, AC Obermeyer… - …, 2019 - ACS Publications
Protein–polymer bioconjugate self-assembly has attracted a great deal of attention as a
method to fabricate protein nanomaterials in solution and the solid state. To identify protein …

Elastin-like polypeptide (ELP) charge influences self-assembly of ELP–mCherry fusion proteins

CE Mills, Z Michaud, BD Olsen - Biomacromolecules, 2018 - ACS Publications
Self-assembly of protein–polymer bioconjugates presents an elegant strategy for controlling
nanostructure and orientation of globular proteins in functional materials. Recent work has …

Structural characterization of protein–polymer conjugates for biomedical applications with small-angle scattering

JK Pokorski, MJA Hore - Current Opinion in Colloid & Interface Science, 2019 - Elsevier
Protein–polymer conjugates, typically consisting of one or more polymers covalently
attached to a protein, are an increasingly common component in biotechnology. Polymers …

Topology effects on protein–polymer block copolymer self-assembly

T Suguri, BD Olsen - Polymer Chemistry, 2019 - pubs.rsc.org
Bioconjugates made of the model red fluorescent protein mCherry and synthetic polymer
blocks show that topology, ie the BA, BA2, ABA and ABC chain structure of the block …