Opioid receptor desensitization: mechanisms and its link to tolerance
S Allouche, F Noble, N Marie - Frontiers in pharmacology, 2014 - frontiersin.org
Opioid receptors (OR) are part of the class A of G-protein coupled receptors and the target of
the opiates, the most powerful analgesic molecules used in clinic. During a protracted use, a …
the opiates, the most powerful analgesic molecules used in clinic. During a protracted use, a …
Post-translational modifications of opioid receptors
Post-translational modifications (PTMs) are key events in signal transduction since they
affect protein function by regulating their abundance and/or activity. PTMs involve the …
affect protein function by regulating their abundance and/or activity. PTMs involve the …
Role of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: a site specific focus
SM Ahmadi-Soleimani, H Azizi, HS Gompf… - …, 2017 - Elsevier
Orexin-A and-B neuropeptides are exclusively synthesized in hypothalamic neurons. These
have been implicated to play critical roles in the expression of various behavioral …
have been implicated to play critical roles in the expression of various behavioral …
Cellular tolerance at the µ-opioid receptor is phosphorylation dependent
Phosphorylation of the μ-opioid receptor (MOR) is known as a key step in desensitization
and internalization but the role in the development of long-term tolerance at the cellular level …
and internalization but the role in the development of long-term tolerance at the cellular level …
GRKs as key modulators of opioid receptor function
Understanding the link between agonist-induced phosphorylation of the mu-opioid receptor
(MOR) and the associated physiological effects is critical for the development of novel …
(MOR) and the associated physiological effects is critical for the development of novel …
Neural correlates and potential targets for the contribution of orexin to addiction in cortical and subcortical areas
The orexin (hypocretin) is one of the hypothalamic neuropeptides that plays a critical role in
some behaviors including feeding, sleep, arousal, reward processing, and drug addiction …
some behaviors including feeding, sleep, arousal, reward processing, and drug addiction …
[引用][C] Chronic treatment with morphine disrupts acute kinase-dependent desensitization of GPCRs
ER Leff, S Arttamangkul, JT Williams - Molecular pharmacology, 2020 - ASPET
[引用][C] Agonist-Specific Regulation of G Protein–Coupled Receptors after Chronic Opioid Treatment
S Adhikary, O Koita, JJ Lebowitz, WT Birdsong… - Molecular …, 2022 - ASPET
[引用][C] Desensitization and tolerance of mu opioid receptors on pontine Kölliker-Fuse neurons
ES Levitt, JT Williams - Molecular pharmacology, 2018 - ASPET