Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …

Enhancing the regeneration of axons is often considered to be a therapeutic target for
improving functional recovery after peripheral nerve injury. In this review, the evidence for …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Background Increasing pre-clinical evidence suggests that aerobic exercise positively
modulates neuroimmune responses following traumatic nerve injury. However, meta …

After a dorsal root crush injury, centrally-projecting sensory axons fail to regenerate across
the dorsal root entry zone (DREZ) to extend into the spinal cord. We find that chemogenetic …

Motoneurons axotomized by peripheral nerve injuries experience profound changes in their
synaptic inputs that are associated with a neuroinflammatory response that includes local …

Injured peripheral nerves regenerate their axons in contrast to those in the central nervous
system. Yet, functional recovery after surgical repair is often disappointing. The basis for …

One hour of 20-Hz continuous electrical stimulation (ES) applied at the time of injury
promotes the regeneration of axons in cut peripheral nerves. A more robust enhancement of …

Peripheral nerve injuries are common, and functional recovery is very poor. Beyond surgical
repair of the nerve, there are currently no treatment options for these patients. In …

Brief neuronal activation in injured peripheral nerves is both necessary and sufficient to
enhance motor axon regeneration, and this effect is specific to the activated motoneurons. It …