Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer

BS Katzenellenbogen, VS Guillen… - Breast Cancer …, 2023 - Springer
Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly
upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and …

FOXM1: From cancer initiation to progression and treatment

CY Koo, KW Muir, EWF Lam - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological
processes, including cell proliferation, cell cycle progression, cell differentiation, DNA …

[HTML][HTML] FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance

S Zona, L Bella, MJ Burton, GN de Moraes… - Biochimica Et Biophysica …, 2014 - Elsevier
FOXM1 is a transcription factor required for a wide spectrum of essential biological functions,
including DNA damage repair, cell proliferation, cell cycle progression, cell renewal, cell …

Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells

N Khera, AS Rajkumar, K Abdulkader M Alkurdi, Z Liu… - Molecular Cancer, 2023 - Springer
Multidrug resistance renders treatment failure in a large proportion of head and neck
squamous cell carcinoma (HNSCC) patients that require multimodal therapy involving …

FOX (M1) news—it is cancer

M Halasi, AL Gartel - Molecular cancer therapeutics, 2013 - AACR
FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined
role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in …

FOXM1: a multifunctional oncoprotein and emerging therapeutic target in ovarian cancer

C Liu, CJ Barger, AR Karpf - Cancers, 2021 - mdpi.com
Simple Summary Ovarian cancer is a lethal disease in women with a 10-year survival rate
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

NG Nikitakis, M Pentenero, M Georgaki, CF Poh… - Oral surgery, oral …, 2018 - Elsevier
Identification and management of potentially premalignant oral epithelial lesions (PPOELs)
at highest risk of malignant transformation holds great promise for successful secondary …

The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological …

I Wierstra - Advances in cancer research, 2013 - Elsevier
Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling

VN Kristensen, CJ Vaske… - Proceedings of the …, 2012 - National Acad Sciences
We use an integrated approach to understand breast cancer heterogeneity by modeling
mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing …

Identification of gastric cancer subtypes based on pathway clustering

L Li, X Wang - npj Precision Oncology, 2021 - nature.com
Gastric cancer (GC) is highly heterogeneous in the stromal and immune microenvironment,
genome instability (GI), and oncogenic signatures. However, a classification of GC by …