Systemic amyloidosis is a rare protein misfolding and deposition disorder leading to
progressive organ failure. There are over 15 types of systemic amyloidosis, each caused by …

Advances in cardiac imaging have resulted in greater recognition of cardiac amyloidosis in
everyday clinical practice, but the diagnosis continues to be made in patients with late-stage …

Since the inception of the Canadian Cardiovascular Society heart failure (HF) guidelines in
2006, much has changed in the care for patients with HF. Over the past decade, the HF …

Monoclonal gammopathy of renal significance (MGRS) regroups all renal disorders caused
by a monoclonal immunoglobulin (MIg) secreted by a nonmalignant B-cell clone. By …

The combination of cyclophosphamide/bortezomib/dexamethasone (CyBorD) showed early
promise of high rates of hematologic responses tempered by studies showing the inability to …

The systemic amyloidoses are a family of diseases induced by misfolded or misassembled
proteins. Extracellular deposition of these proteins as soluble or insoluble cross-sheets …

Background—Differentiating immunoglobulin light-chain (AL) from transthyretin-related
cardiac amyloidoses (ATTR) is imperative given implications for prognosis, therapy, and …

Abstract Treatment outcomes of patients with cardiac stage III light chain (AL) amyloidosis
remain poorly studied. Such cases have been excluded from most clinical studies due to …

Objectives This study aimed to assess the diagnostic use of native T1 to detect cardiac
amyloidosis (CA) in a large prospective cohort of patients referred for suspected systemic …

Familial amyloid polyneuropathies (FAPs) are a group of life-threatening multisystem
disorders transmitted as an autosomal dominant trait. Nerve lesions are induced by deposits …