Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate
various biological effects including membrane excitability, synaptic transmission and …

During the winter, hibernating mammals undergo extreme changes in physiology, which
allow them to survive several months without access to food. These animals enter a state of …

Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …

Schizophrenia (SZ) is a serious mental illness and neuropsychiatric brain disorder with
behavioral symptoms that include hallucinations, delusions, disorganized behavior, and …

Biological processes unfold across broad spatial and temporal dimensions, and
measurement of the underlying molecular world is essential to their understanding …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

Bone defects and fractures present significant clinical challenges, particularly in orthopedic
and maxillofacial applications. While minor bone defects may be capable of healing …

Cell–cell signaling peptides (eg, peptide hormones, neuropeptides) are among the largest
class of cellular transmitters and regulate a variety of physiological processes. To identify …

Protein database search engines are an integral component of mass spectrometry-based
peptidomic analyses. Given the unique computational challenges of peptidomics, many …