The laboratory mouse has become the predominant test species in biomedical research.
The number of papers that translate or extrapolate data from mouse to human has grown …

Global rates of obesity continue to rise and are necessarily the consequence of a long-term
imbalance between energy intake and energy expenditure. This is the result of an …

Objectives The laboratory mouse is presently the most common model for examining
mechanisms of human physiology and disease. Housing temperatures can have a large …

Human and mouse thermal physiology differ due to dissimilar body sizes. Unexpectedly, in
mice we found no ambient temperature zone where both metabolic rate and body …

The current obesity pandemic results from a physiological imbalance in which energy intake
chronically exceeds energy expenditure (EE), and prevention and treatment strategies …

The issue under discussion here is whether a decrease in the degree of UCP1 activity (and
brown adipose tissue activity in general) could be a cause of obesity in humans. This …

A basic property of endothermic thermoregulation is the ability to generate heat by
increasing metabolism in response to cold ambient temperatures to maintain a stable core …

Animals that lack the hormone leptin become grossly obese, purportedly for 2 reasons:
increased food intake and decreased energy expenditure (thermogenesis). This review …

New Findings What is the topic of this review? It has been suggested that human brown
adipose tissue (BAT) is more similar to the brite/beige adipose tissue of mice than to …

The significance of diet-induced thermogenesis (DIT) for metabolic control is still debated.
Although obesogenic diets recruit UCP1 and adrenergically inducible thermogenesis, and …