Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a
fundamental role in metazoan development. Signals exchanged between neighboring cells …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …

Aberrant activation of Notch receptors has been shown to cause mammary tumors in mice.
We therefore used in situ hybridization to analyze expression of Notch ligands and receptors …

Endocytosis of the ligand Delta is required for activation of the receptor Notch during
Drosophila development. The Notch extracellular domain (NotchECD) dissociates from the …

Introduction 3. Stem cells and mesenchymal stem cells 4. Mesenchymal stem cell lineages
4.1. Myogenic lineage 4.2. Adipogenic lineage 4.3. Chondrogenic lineage 4.4. Osteogenic …

It was previously shown that the NF-κB pathway is downstream of oncogenic Notch1 in T cell
acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-κB activation …

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate
in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) …

Phosphorylation of Notch proteins has been indirectly correlated with Notch activation and
nuclear translocation as well as cellular transformation. There is evidence that the Wnt …

Notch-1 belongs to a family of transmembrane receptor proteins that direct the decisions as
to various cell fates. After ligand binding, a proteolytic cleavage step occurs and the …