Abstract The EGFR/Erb-B receptor tyrosine kinases each play distinct and complementary
roles in normal breast development. The four receptors form both homodimers and …

Tumor metabolism is significantly altered to support the various metabolic needs of tumor
cells. The most prominent change is the increased tumor glycolysis that leads to increased …

Hypoxia plays a critical role in tumor progression including invasion and metastasis. To
determine critical genes regulated by hypoxia that promote invasion and metastasis, we …

Elucidating the molecular drivers of human breast cancers requires a strategy that is
capable of integrating multiple forms of data and an ability to interpret the functional …

Although significant variations in the metabolic profiles exist among different cells, little is
understood in terms of genetic regulations of such cell type–specific metabolic phenotypes …

Abstract Background Hypoxia-inducible factors (HIFs) are well-established mediators of
tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several …

Introduction Overexpression of the oxygen-responsive transcription factor hypoxia-inducible
factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The mouse …

Background A variety of oncogenic and environmental factors alter tumor metabolism to
serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis …

The tumor stromal environment can dictate many aspects of tumor progression. A complete
understanding of factors driving stromal activation and their role in tumor metastasis is …

Introduction Remodeling of cellular metabolism appears to be a consequence and possibly
a cause of oncogenic transformation in human cancers. Specific aspects of altered tumor …