Current translational potential and underlying molecular mechanisms of necroptosis
Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
Necroptosis is a type of programmed cell death with great significance in many pathological
processes. Tumour necrosis factor-α (TNF), a proinflammatory cytokine, is a prototypic …
processes. Tumour necrosis factor-α (TNF), a proinflammatory cytokine, is a prototypic …
Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
K Weber, R Roelandt, I Bruggeman, Y Estornes… - Communications …, 2018 - nature.com
Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the
necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key …
necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key …
[HTML][HTML] Post-translational control of RIPK3 and MLKL mediated necroptotic cell death
Several programmed lytic and necrotic-like cell death mechanisms have now been
uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3) …
uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3) …
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3
The auto-phosphorylation of murine receptor-interacting protein 3 (Rip3) on Thr 231 and Ser
232 in the necrosome is required to trigger necroptosis. However, how Rip3 phosphorylation …
232 in the necrosome is required to trigger necroptosis. However, how Rip3 phosphorylation …
Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL
J Li, X Liu, Y Liu, F Huang, J Liang, Y Lin, F Hu… - Cell Death & …, 2024 - nature.com
Necroptosis is a kind of programmed cell death that causes the release of damage-
associated molecular patterns and inflammatory disease including skin inflammation …
associated molecular patterns and inflammatory disease including skin inflammation …
CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux
ABSTRACT MLKL (mixed lineage kinase domain like pseudokinase) is a well-known core
component of necrosome that executes necroptotic cell death upon phosphorylation by …
component of necrosome that executes necroptotic cell death upon phosphorylation by …
Cisplatin-induced necroptosis in TNFα dependent and independent pathways
Cisplatin is a chemotherapeutic drug for treatment of many solid tumors. It has been shown
to induce apoptosis and/or necrosis in different types of cancer cells. However, the …
to induce apoptosis and/or necrosis in different types of cancer cells. However, the …
SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
D Wang, Y Lin, F Xu, H Zhang, X Zhu, Z Liu, Y Hu… - …, 2022 - thelancet.com
Background To determine whether SIRPα can be a diagnostic marker of pulmonary
tuberculosis (PTB) and the molecular mechanism of SIRPα regulating macrophages to kill …
tuberculosis (PTB) and the molecular mechanism of SIRPα regulating macrophages to kill …
Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16
HY Yu, Y Li, M Zhang, ZB Zou, YJ Hao… - Chemistry & …, 2023 - Wiley Online Library
Abstract One new alkaloid,(S)‐2‐acetamido‐4‐(2‐(methylamino) phenyl)‐4‐oxobutanoic
acid (1), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with …
acid (1), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with …