Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

Evidence is reviewed that free fatty acids (FFAs) are one important link between obesity and
insulin resistance and NIDDM. First, plasma FFA levels are elevated in most obese subjects …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

We review evidence that increased tissue levels of fatty acyl CoA cause the β-cell
abnormalities of nondiabetic obesity and ultimately result in obesity-dependent diabetes …

Obesity is commonly associated with elevated plasma free fatty acid (FFA) levels, as well as
with insulin resistance and hyperinsulinemia, two important cardiovascular risk factors. What …

Evidence is presented that shows that free fatty acids (FFA) are one important link between
obesity, insulin resistance, and type 2 diabetes. Plasma FFA levels are elevated in most …

Effects of free fatty acids (FFAs) on endogenous glucose production (EGP) and
gluconeogenesis (GNG) were examined in healthy subjects (n= 6) during stepwise …

Suppression of hepatic glucose output (HGO) has been shown to be primarily mediated by
peripheral rather than portal insulin concentrations; however, the mechanism by which …

Activation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-
β-d-ribofuranoside (AICAR) increases glucose transport in skeletal muscle via an insulin …

To establish the antihyperglycemic mechanisms of metformin in non-insulin-dependent
diabetes mellitus (NIDDM) independently of the long-term, aspecific effects of removal of …