No current methods can selectively elicit an antibody response to a specific conformational
epitope in a whole antigen in vivo. Here, we incorporated N ε-acryloyl-l-lysine (AcrK) or N ε …

Background Diabetic nephropathy (DN) is a serious vascular complication of diabetes and
an important cause of end-stage renal disease. One mechanism by which hyperglycemia …

Agents that inhibit glycation end products by reducing the carbonyl load from glycation and
glycoxidation are an emerging pharmacologic approach to treat complications of diabetes …

Penyebab utama kematian pada pasien diabetes adalah komplikasi. Advanced glycation
end product (AGE) berperan penting dalam proses dan peningkatan derajat keparahan …

The maturation of B cells leads to the synthesis of highly evolved immunoglobulins (Igs) that
enable efficient antigen‐antibody recognition. Here we discuss a non‐opportunistic …

Antibody affinity is critically important in therapeutic applications, as well as steady state
diagnostic assays. Picomolar affinity antibodies, approaching the association limit of protein …

A61K47/50—Medicinal preparations characterised by the non-active ingredients used, eg
carriers or inert additives; Targeting or modifying agents chemically bound to the active …

Non-enzymatic protein glycation is a source of metabolic stress that contributes to
cytotoxicity and tissue damage. Hyperglycemia has been linked to elevation of advanced …

Неферментативное гликирование белков является причиной метаболического стресса,
который приводит к цитотоксичности и вызывает повреждения тканей. Гипергликемия …

Diabetes mellitus merupakan penyakit degeneratif dimana terjadi kondisi hiperglikemia
kronis yang mampu mengakibatkan berbagai macam komplikasi yang dipicu oleh …