Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …
SIRT1 and p53, effect on cancer, senescence and beyond
NAD+-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically
involved in stress responses, cellular metabolism and aging through deacetylating a variety …
involved in stress responses, cellular metabolism and aging through deacetylating a variety …
[HTML][HTML] Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration
Many adult tissues contain resident stem cells, such as the Pax7+ satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
[HTML][HTML] Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure
Abstract Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde
dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and …
dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and …
[HTML][HTML] Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression
T Wu, W Wang, G Shi, M Hao, Y Wang, M Yao… - Cell Death & …, 2022 - nature.com
Prostate cancer (PCa) is a malignant tumor that seriously threatens men's health worldwide.
Recently, stromal cells in the tumor microenvironment (TME) have been reported to …
Recently, stromal cells in the tumor microenvironment (TME) have been reported to …
[HTML][HTML] Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult
M Arostegui, RW Scott, K Böse, TM Underhill - Nature Communications, 2022 - nature.com
Tissue development and regeneration rely on the cooperation of multiple mesenchymal
progenitor (MP) subpopulations. We recently identified Hic1 as a marker of quiescent MPs in …
progenitor (MP) subpopulations. We recently identified Hic1 as a marker of quiescent MPs in …
Reviving the guardian of the genome: Small molecule activators of p53
The tumor suppressor p53 is one of the most important proteins for protection of genomic
stability and cancer prevention. Cancers often inactivate it by either mutating its gene or …
stability and cancer prevention. Cancers often inactivate it by either mutating its gene or …
[HTML][HTML] Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer …
Over-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1,
also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring …
also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring …
[HTML][HTML] FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer
J Yao, J Yang, Z Yang, XP Wang, T Yang, B Ji… - Cell Death & …, 2021 - nature.com
Colorectal tumorigenesis is a heterogeneous disease driven by multiple genetic and
epigenetic alterations. F-box and WD repeat domain containing 11 (FBXW11) is a member …
epigenetic alterations. F-box and WD repeat domain containing 11 (FBXW11) is a member …
Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells
Although DNA hypermethylation within promoter CpG islands is highly correlated with
tumorigenesis, it has not been established whether DNA hypermethylation within a specific …
tumorigenesis, it has not been established whether DNA hypermethylation within a specific …