The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

Highlights•Quantitative measurements of 40 proteins or mRNA species per cell.•Antibodies
labeled with isotopes instead of fluorophores.•Deep cell profiling of functional network …

The role of B-cell receptor (BCR)–mediated survival signals in diffuse large B-cell lymphoma
(DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor …

The 2 subsets of chronic lymphocytic leukemia (CLL), of worse or better prognosis, likely
derive from pre-GC unmutated B cells, or post-GC mutated B cells, respectively. Different …

Objective Breg cells, a regulatory cell subset that produces interleukin‐10 (IL‐10), play a
significant role in suppressing autoimmune responses and preventing autoimmunity. This …

Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found
previously that the Ig in FL is unusual, because the variable region genes carry sequence …

Memory B cells are comprised of unswitched (CD27+ IgD+) and switched (CD27+ IgD-)
subsets. The origin and function of unswitched human memory B cells are debated in the …

Drug screening is often limited to cell-free assays involving purified enzymes, but it is
arguably best applied against systems that represent disease states or complex …

Defects in T-cell function in patients with cancer might influence their capacity to mount
efficient antitumor immune responses. Here, we identified highly reduced IL-4–, IL-10–, and …