Obesity is a complex, chronic medical condition with a major negative impact on human
health. 1 Over the last 30 years, there has been an exponential growth in the prevalence of …

Exome sequencing has been commonly used to characterize rare diseases by selecting
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …

The variation in weight within a shared environment is largely attributable to genetic factors.
Whilst many genes/loci confer susceptibility to obesity, little is known about the genetic …

Different exposures, including diet, physical activity, or external conditions can contribute to
genotype–environment interactions (G× E). Although high-dimensional environmental data …

Abstract Gene-environment (G× E) interaction could partially explain missing heritability in
traits; however, the magnitudes of G× E interaction effects remain unclear. Here, we estimate …

The prevalence of obesity has been increasing markedly in the US and worldwide in the
past decades; and notably, the obese populations are signified by not only the overall …

MC4R, LEP, and LEPR genes are involved in the hypothalamic leptin-melanocortin
regulation pathway, which is important for energy homeostasis. Our study aimed to evaluate …

Objectives Obesity is a significant risk factor for a number of chronic diseases, including
diabetes, cardiovascular diseases, and cancer. Obesity usually results from a combination of …

Background The rs9939609 SNP in fat mass and obesity-associated (FTO) gene influence
obesity, whose effects might be mediated by lifestyle factors. However, evidence was lacked …

The present study investigated whether dietary patterns could interact with fat mass and
obesity-associated (FTO) polymorphisms in relation to changes in BMI and waist …